Antidepressants and Nursing

by Alan Greene, MD, FAAP

More women become depressed while their children are babies than at any other time in life (Clin Pharmacokinet 1994 Oct;27(4):270-89). With the surging tide of postpartum hormones, mounting sleep deprivation, persistent noise, shifting body image, the change of life structure, and the loss of control of one's own time, this depression is not surprising -- even with a brand-new bundle of joy in the home.

For a nursing mother, making the decision to take medicine to treat this depression is tricky. We know some medicines are not safe to take when nursing; others are okay. For most medicines, there is not enough known to do better than make an educated guess. Most of the antidepressants fall into this last category.

Since most medications of any kind taken by the mother do show up in the breast milk, my rule of thumb is that, all other things being equal, it is better for a nursing mom not to take a medicine that is not clearly okay to prescribe for the baby.

With Depression, All Other Things Aren't Equal

Solid evidence is mounting that maternal depression is not good for babies' development. A study released just last month looked at 225 four-month-old infants, and their responses to the voices of depressed and non-depressed women. Babies do not learn as well when they are listening to the flatter, less melodic voices of depressed women. Adults' perky, high-pitched baby talk sets the stage for intellectual development (Child Development 1999;70:560-570).

Depressed mothers deserve treatment, both for their babies' sakes, and so that the mothers do not miss out on enjoying one of life's unrepeatable joys -- the all-too-brief babyhood of each child.

It's best to treat the depression with sleep, exercise, bright light, upbeat music, and healthy food. Exercise is particularly difficult in the postpartum period -- both time and energy are often lacking. But exercise has been proven to help specifically with postpartum depression (J Sports Med Phys Fitness 1997 Dec;37(4):287-91). Cooperation and commitment will be needed from family and friends to guard Mom's sleep and to free her up for daily aerobic exercise -- outside if possible (Prev Med 1999 Jan;28(1):75-85). An hour of aerobic exercise daily can be as powerful as even the strongest antidepressant medications. Even 10 minutes a day can make a noticeable difference.

Anaerobic exercise, while effective at treating depression, creates lactic acid that causes sore muscles. This lactic acid gets into the breast milk. It doesn't taste good and leads to fussier babies -- which in turn increases the risk of depressed moms (Pediatrics 1992 Jun;89(6 Pt 2):1245-7). I also wonder whether depression itself may alter breast milk, giving another good reason to treat.

Even an hour of quiet rest with no responsibilities can significantly improve the depressed symptoms (J Sports Med Phys Fitness 1997 Dec;37(4):287-91). If treating the depression without medicines isn't satisfactory, I am in favor of using antidepressant medicines.

Should Mom Discontinue Nursing?

We know that nursing is of tremendous benefit in a great many ways. The magnitude of the value depends partly on the age of the baby. Breast milk is much more important for a 3-month-old than for a 13-month old.

What do we know of the hazards of antidepressants? The use of antidepressant medications during nursing has not been systematically investigated. The medical literature is peppered with case reports and small, uncontrolled studies. These publications span over three decades, but the largest single study by one group of investigators examined 12 mother-infant pairs (J Clin Psychiatry 1998;59 Suppl 2:41-52). There is not enough information to make firm guidelines, but there is enough to reach educated opinions.

We do know that while all antidepressant medicines show up in the breast milk the babies drink, the different medications are excreted into breast milk in different amounts. In general, the more fat-soluble the drug is, the higher the concentration in breast milk. Other factors, such as the pH of the drug, also make a difference.

The goal is to minimize the amount of antidepressant the baby drinks while maximizing mom's emotional health. Each situation deserves individual consideration.

Comments

Yes and I may say that it is normal for a pregnant mom to be more easily irritated or annoyed by anything or anyone in her surroundings, but we are all aware that taking any medicine may be more dangerous than helpful.

Given the history of the FDA, it should be no surprise that a "medicine" like Ambien should turn out to be dangerous.

Granted, there are drug side effects for every medication – technically, there are side effects of taking a placebo. A sleep aid that causes people to not go to sleep, plus dangerous side effects like narcolepsy and/or sleep walking…bad news. Doctors often recommend getting more exercise, and trying herbal remedies – a glass of good red wine has always helped me.