Is the recommended daily dose of folic acid enough for everyone?

Spina bifida continues to be the most common permanently disabling birth defect and recent publications suggest spina bifida is estimated to occur in 1 in 2,858 pregnancies each year in the U.S. New methods for assessing a woman’s risk by examining the genetics in her folate pathway may allow doctors to intervene with a prescription regimen early enough to reduce the number of children born with spina bifida. Learn more about the scientific study.

Medical references:
- American College of Obstetricians and Gynecologists (ACOG). Neural tube defects. Washington (DC): American College of Obstetricians and Gynecologists (ACOG); 2003 Jul. 11 p. (ACOG practice bulletin; no. 44).
- De-Regil LM, Fernández-Gaxiola AC, Dowswell T, Peña-Rosas JP. Effects and safety of periconceptional folate supplementation for preventing birth defects. Cochrane Database Syst Rev 2010;CD007950.
- Parker SE, Mai, CT, Canfield MA et al. 2010. Updated National Birth Prevalence Estimates for Selected Birth Defects in US 2004-2006. Birth Defects Research (Part A) 88:1008-1016.