Torn- Zofran

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TessaS's picture
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Torn- Zofran

Oh ladies, I am so sick. I know it is a common thing for around 8 weeks pregnant, but I haven't had a good meal over a week, but I think I threw up 10 times yesterday. I was able to keep a little bit of food (1/2 a sandwhich) down lastnight, which was a good thing, but before that I hadn't been able to for over 24 hours. Uk...so hard to work like that. With my husband hurt and home for awhile I have to work to keep up our insurance. Can hardly function. Yesterday I got a prescription for Zofran. I know there was some connections to nasty stuff like miscarriages, and that sounds so scary for me. My sister told me she got he prescription and didn't think it was worth the risk so she just waited it out. I don't think I can though. I am not trying to make anyone feel guilty for taking Zofran, I just want reasurance that it is ok. My dh is a little hesident too, because of the risks. My sister-in-law took it and has had no issues.

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I have a friend who is taking Zofran because she was so sick. She says it doesn't completely take away the nausea but it definitely takes the edge off. And she said she didn't take it with her first pregnancy because she was so paranoid about taking any drugs. Now with her second pregnancy she is so glad she decided to take it. She also recommends trying to get the generic version if that is possible. Good luck!!

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Hi there, I'm new to this thread (I just took my pregnancy test yesterday - due July 27.) I am a PhD student in Biostatistics, and like to do health research.

So reading your post, I just found a 2010 New England Journal of Medicine review article about nausea and vomiting during pregnancy, summarizing all the latest research. It recommended that if you are sick enough to be losing weight, you should take something to reduce the nausea. "Losing weight" is the trigger point when the benefits outweight the risks. The article actually suggested vitamin B6 as a first thing to take and then some other drug (doxyclimine), and then Zofran. It also said ginger can be added to any other therapy at any time. People taking Zofran have never been shown to have more miscarriages than other groups. In fact, in the one study that was done (looking at 200 women with nausea), the miscarriage rate was lower than what is seen in the population. This is because nausea (unfortunately or fortunately) has a protective effect for the baby, ie people with nausea are much less likely to miscarry than people without nausea...

I posted to this board a long time ago with my first child, and there sure was a lot of nervousness, and not knowing how to separate fact from fiction... There is a lot of information and misinformation out there, and people without a degree in epidemiology would have a very hard time sifting through it. I would suggest talking to your doctor (whose job it is to sift through it) if you have worries about these things.

I'd probably personally try the B6 and the ginger first, because I'm a "no drug" kind of girl, but if nothing else is working, I would take the Zofran.

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aph, has your friend had her baby yet? I am glad to hear that she has had some luck. I just want to stop vomiting. Thanks you Smile

sooky, congrats and welcome to July! I very much appreciate your advice and expertise. That is exactly what my doctor told me about the concern about my lack of nourishment. She was concerned that if my nausea is starting out this bad this fast it probably will last another month. I actually did try B6 and doxyclimine (recommended by my doctor first) for the past five days...didn't touch my symptoms...I actually just finished my first liter of ginger ale. Has helped a bit Smile Also tried lemon drops which helped, until I developed an aversion for them (just thinking about it makes me slightly sick). I am very relieved to hear your results on the study with Zofran. I have tried to do some research, but when reading makes me sick it is hard lol. I got most of my info from my sister, and I am not sure what she had to back that up. So, as far as you can tell, Zofran is safe? I am just now getting pretty nauseous and trying to keep down the meager breakfast I had...thinking about taking one of the Zofran.

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Hi, sorry, that was my first post above, and I didn't tell you my name. Its Elizabeth. Smile

Sounds like your doctor is following "best practice". Exactly the right thing to do! The drug is category B which means it has been tested extensively in pregnant animals with far higher than the regular dose (per bodyweight) than a human would ever be subjected to, and it proved to be safe. Studies with humans have not shown any risk, but they have been underpowered, (ie not enough people to show that the results cannot be attributed to pure chance). However, no risks have ever been proven.

If I was as sick as you, knowing what I now know, I would take the Zofran. I would not pay any heed to incidental reports of Zofran causing miscarriage. You can always find an incidental report of something being blamed for something else (particuarly in pregnancy...its crazy the things that circulate!). However, unless someone has found a specifical biological causal pathway, or has shown a statistical association in a large epidemiological study, these single incidents can be due to pure chance and cannot outweigh the thousands of women who take it and have no problems at all.

There's a great website in Canada, called www.motherrisk.org, that is devoted to looking at drugs and pregnancy. In fact, they sponsored the one study done in women that I mentioned above... I used it when I wanted to look up drugs last time I was pregnant...

Elizabeth

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Elizabeth Smile I went ahead and I took it because I was feeling pretty ickey...what a difference. Still feel nausous, but able to function. Still haven't brought myself to eat more than a few crackers here for lunch...I don't know. Even thinking about eating anything else, just thinking, makes me feel worse. Going to wait a little more and try some noodles or something.

I will check out that website, ty!

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Hi. I just want to add that I have been seeing an acupuncturist and went on Monday. I felt so nauseated and I asked her to work on that. The treatment took the edge off and then she gave me these tiny bandaids with a teeny tiny needletip that she put on my wrists. It takes the edge off so much. I can eat (some) and I haven't dry heaved since I got them. I am wearing them 24-7 and they are awesome. I have heard some people wear the "seabands" that have the acupressure at the same point and get relief. Anyway, another thing to try. If Zofran is working, I would keep that up too. Hope you feel better soon.