i have a diagnosis - finally! (MC Ment)

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kadibug's picture
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i have a diagnosis - finally! (MC Ment)

i had to take a break from on-line forums, so i've been gone for a while.

since my last loss was a tri18, the RE ran a test for my AMH (anti mullarian hormone) and discovered that it is low - 1.22. this means i have low ovarian reserve. my FSH tested fine on day 3 b/c my ovaries the right amount of FSH to ovulate but for some reason, i have less eggs. woman with less eggs have a higher chance of tri18, tri13, and m/c's. the doc said i am 32 but my fertility is more like someone in their late 30's.

this was crushing as having AMH at 1.22 means less success with IUI and IVF. dh and i are planning three more IUI's this spring and IVF this summer even though we were told that i might not produce enough quality eggs to have any left for FET Sad ... pretty stressful to think that i have one shot at IVF.

we also found out that dh has low testosterone. he was on a lot of steroids for years in his early 20's due to ulcertive colitis and having a colonectomy done (spelling?!). he is going on meds.

i never though a diagnosis would come for us, but it did. i am so devastated that it's low ovarian reserve, but i am relieved to know why i can't stay pg and had a baby with defects.

i am still heartbroken about my tri18 but i have made great steps in accepting its passing. sometimes i think of its last u/s and get emotional, but i've accepted that it's gone and will never come back. that was so hard.

take care and good luck to everyone!

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I am so very sorry to hear of your losses. *Hugs* I wish you and your husband all the best in the new year!

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Sorry to hear about your diagnosis.. Are you and DH going to consider the FET?

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I haven't been on this board in years, but saw your post and thought I would stop by. I am so sorry about your recurrent losses and hope that you have a healthy, successful pregnancy soon. I received the same diagnosis when I was about the same age you are now. It is devastating news, but don't lose hope. There's a book that I recommend titled, "Inconceivable." I'm at work and can't recall the author's full name...Indichova is her last name though. I've read it multiple times.

PG MENT
It took us three years to get pregnant with our DS (he's 17 months now). We went through femara/IUI cycles, 2 failed IVF cycles (only produced 1 embryo first cycle and 2 the second cycle...none divided past 4 cells), and injectable/IUI cycles. We were almost ready to move on to donor eggs when we had success with an injectable/IUI cycle that we only tried because we had a bunch of leftover Follistim.

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So sorry about your losses! I agree that you shouldn't loose hope (although it's easier said than done). I hope with a diagnosis you can finally go down the right path and have a healthy baby soon!! :bighug:

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Hi there. Please don't lose hope. It sounds like you have a good plan in place (IUI's, then IVF).

I am sorry that your numbers indicate low ovarian reserve, but I want to tell you my experience. I recently had my AMH # taken, and it came up .89. My new RE told me this borderline low for my age (36). His exact words were, "if you want to be aggressive, now is the time", and in a year, I wouldn't respond to the drugs as well. He did not tell me my chances now were terrible at all (30%) for IVF. My chances of natural conception/IUI were terrible, but that was because of my tubal problems.

Also, about a year ago, I had my AMH taken, it was 1.0 and that RE never mentioned it at all! I was told all my labs were normal, and the only reason I know it was 1.0 is because I saw it when I had my records to bring to my new doctor. My FSH numbers have always been fine, and several ultrasounds I had at the beginning of my cycle within the last year showed normal number of follicles. One nurse even told me I had "young ovaries" by the way it looked on US. To find out I had low AMH, and what that meant, was surprising. I am trying not to think about it too much, honestly.

I guess my point is that my doctor is optimistic that right now, I would respond okay to drugs for IVF and have a decent chance at a baby, and my number is a lot lower than yours. So there must be differing opinions on what low really is. I guess I'll find out for sure when we start IVF.

I hope that makes you feel a bit better. I really think you still have a decent chance. Good luck and keep us posted.

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Huge hugs lovely.
I am glad you finally had a diagnosis.
I hope with this they can make a plan of action for you xxxx

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overthemoon - i too was told that my time to conceive was now or never. i have about 2 years left before i will be entirely infertile. like you, all my other tests came back fine! i have about 5 follies each time i do clomid. little did i know that my reserve was horrible. 1.22 is low for age 32. by 34, i was told, it will be too low for conception. that's depressing to hear!

i was told that ivf would be about 50% chance for us, knowing that the longer we wait, the lower our odds are. gosh, that's so frustrating. if i had known this would happen, i wouldn't have waited so long to start trying, although i don't know how that would have worked out. i met my dh at 27, married at 29, started ttc at 30... what was i suppose to do? get knocked up? i have nothing against that idea, but an unmarried pregnant teacher doesn't go over well in utah - LOL

what were you told about FET? i was told that there probably won't be enough "good" eggs to have enough for FET.

"overthemoon" wrote:

Hi there. Please don't lose hope. It sounds like you have a good plan in place (IUI's, then IVF).

I am sorry that your numbers indicate low ovarian reserve, but I want to tell you my experience. I recently had my AMH # taken, and it came up .89. My new RE told me this borderline low for my age (36). His exact words were, "if you want to be aggressive, now is the time", and in a year, I wouldn't respond to the drugs as well. He did not tell me my chances now were terrible at all (30%) for IVF. My chances of natural conception/IUI were terrible, but that was because of my tubal problems.

Also, about a year ago, I had my AMH taken, it was 1.0 and that RE never mentioned it at all! I was told all my labs were normal, and the only reason I know it was 1.0 is because I saw it when I had my records to bring to my new doctor. My FSH numbers have always been fine, and several ultrasounds I had at the beginning of my cycle within the last year showed normal number of follicles. One nurse even told me I had "young ovaries" by the way it looked on US. To find out I had low AMH, and what that meant, was surprising. I am trying not to think about it too much, honestly.

I guess my point is that my doctor is optimistic that right now, I would respond okay to drugs for IVF and have a decent chance at a baby, and my number is a lot lower than yours. So there must be differing opinions on what low really is. I guess I'll find out for sure when we start IVF.

I hope that makes you feel a bit better. I really think you still have a decent chance. Good luck and keep us posted.

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Kadibug Im sorry you have to go through all this I see you're going to do IVF are you going to do the PGD, I think thats what it is. to make sure you babies are ok. I dont understand this whole low AMH thing. I do see other women with it doing micro or mini IVF, because they dont make enough eggs. Good luck and i hope you get your rainbow baby soon.

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mrsdoolittle- thank you for being a ray of hope right now. i do want to know if you have had any m/c before your ds. also, did you have any with defects? the re mentioned that our odds with ivf would be similar - not many good embryos b/c there aren't many good eggs left. it really does seem very hopeless. dh is making plans for what we'll do when we have exhausted all options - iui and ivf.

what was your re's plan for iui? i take clomid cd 3 -7 (make about 3-5 large follies) and then do a shot to induce ovulation two days before the insemination. i am wondering if i should be more aggressive.

"mrs.doolittle" wrote:

I haven't been on this board in years, but saw your post and thought I would stop by. I am so sorry about your recurrent losses and hope that you have a healthy, successful pregnancy soon. I received the same diagnosis when I was about the same age you are now. It is devastating news, but don't lose hope. There's a book that I recommend titled, "Inconceivable." I'm at work and can't recall the author's full name...Indichova is her last name though. I've read it multiple times.

PG MENT
It took us three years to get pregnant with our DS (he's 17 months now). We went through femara/IUI cycles, 2 failed IVF cycles (only produced 1 embryo first cycle and 2 the second cycle...none divided past 4 cells), and injectable/IUI cycles. We were almost ready to move on to donor eggs when we had success with an injectable/IUI cycle that we only tried because we had a bunch of leftover Follistim.

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Kadibug, we didn't exactly talk about FET, but I'll tell you what he did say. I expressed my fears of IVF, of what to do with leftover embryos, and multiples, and the doctor said we'd fertilize 3 eggs, put them in one by one, and freeze the rest of the eggs. So he seemed to think I'd have decent response, I guess.

If the doctor really fears you will not have a good response, would he (and you) consider doing IVF sooner rather than later? Maybe you'd have more embryos to store then. Just a question to ask your doctor.

Sorry you are having to make these decisions. It isn't fair, and 30 is not late to start trying, not in my circles anyway!

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"kadibug" wrote:

i do want to know if you have had any m/c before your ds. also, did you have any with defects?

I am blessed to have been spared any m/c at this point, but there's another poster with ovarian reserve on the IVF board who got pg on her second IVF cycle and m/c (Turner syndrome). Unfortunately, the risk of chromosomal abnormalities increases (as it does with age).

"kadibug" wrote:

the re mentioned that our odds with ivf would be similar - not many good embryos b/c there aren't many good eggs left. it really does seem very hopeless. dh is making plans for what we'll do when we have exhausted all options - iui and ivf.

what was your re's plan for iui? i take clomid cd 3 -7 (make about 3-5 large follies) and then do a shot to induce ovulation two days before the insemination. i am wondering if i should be more aggressive.

Our first IUIs were with femara and no trigger. I think we tried 3 or 4 cycles? Can't remember now because it's been a few years. I just wasn't quite ready mentally to jump to IVF even though the RE pointed out that our chances would be higher. On our first IVF cycle I had 5 eggs which were fertilized with ICSI. My DH has "super sperm," but with my few, fragile eggs they wanted to increase the odds. Only one fertilized and it stopped dividing at 4 cells. My poor response and my obvious egg issue was devastating. We decided to try one more IVF cycle with my eggs. On the second cycle we got 7 eggs. I was thrilled with that! Unfortunately, only 2 fertilized with ICSI and those stopped dividing at 3 and 4 cells. No transfer. Again. I knew I wanted to experience a pregnancy and felt like I had exhausted the possibility of using my own eggs. I was OK with using donor eggs at that point, but we didn't have the financial option of going that route yet. I decided that we should at least use up the Follistim that was leftover (almost $1000 of meds sitting in the veggie drawer of the fridge). I decided I would try acupuncture for 3 cycles prior to an injectable/IUI cycle. My acupuncturist was the only one who seemed optimistic at that point although our RE always said things like, "anything is possible." I produced three follicles by trigger time and was blessed with the healthy pregnancy that resulted in my DS. I still get teary-eyed thinking of how blessed I am. I don't know why it happened when it did, but when I read other stories it seems like it just takes longer for women with low ovarian reserve. There's another good board out there specifically for women with high fsh (or low amh), but I can't think of the name right now. If you're interested, I can find it again. I'm mrs.doolittle on there, too. Wink

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reneakelly - do you mean the amniotic fluid test for pgd? if i do get pg again, i will be recommended to have it done. it wasn't necessary with the last little angel, as the u/s revealed that there was so much fluid it wouldn't make it. the docs thought it was tri13 or 18 or something else lethal right away. the odds of a m/c with the amniotic fluid test scares me though!

"reneakelly" wrote:

Kadibug Im sorry you have to go through all this I see you're going to do IVF are you going to do the PGD, I think thats what it is. to make sure you babies are ok. I dont understand this whole low AMH thing. I do see other women with it doing micro or mini IVF, because they dont make enough eggs. Good luck and i hope you get your rainbow baby soon.
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error

"overthemoon" wrote:

Kadibug, we didn't exactly talk about FET, but I'll tell you what he did say. I expressed my fears of IVF, of what to do with leftover embryos, and multiples, and the doctor said we'd fertilize 3 eggs, put them in one by one, and freeze the rest of the eggs. So he seemed to think I'd have decent response, I guess.

If the doctor really fears you will not have a good response, would he (and you) consider doing IVF sooner rather than later? Maybe you'd have more embryos to store then. Just a question to ask your doctor.

Sorry you are having to make these decisions. It isn't fair, and 30 is not late to start trying, not in my circles anyway!

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overthemoon- DH and I decided that we won't use my eggs for IVF if our last three IUI's fail or produce another tri18/13/defect. My sister offered so we are going to take up he chance to use her eggs. Since I have such low odds of success the first try - up to 50% and almost no chance of an FET... it just makes sense to not place all my eggs in one basket (pun intended).

"overthemoon" wrote:

Kadibug, we didn't exactly talk about FET, but I'll tell you what he did say. I expressed my fears of IVF, of what to do with leftover embryos, and multiples, and the doctor said we'd fertilize 3 eggs, put them in one by one, and freeze the rest of the eggs. So he seemed to think I'd have decent response, I guess.

If the doctor really fears you will not have a good response, would he (and you) consider doing IVF sooner rather than later? Maybe you'd have more embryos to store then. Just a question to ask your doctor.

Sorry you are having to make these decisions. It isn't fair, and 30 is not late to start trying, not in my circles anyway!

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"mrs.doolittle" wrote:

I am blessed to have been spared any m/c at this point, but there's another poster with ovarian reserve on the IVF board who got pg on her second IVF cycle and m/c (Turner syndrome). Unfortunately, the risk of chromosomal abnormalities increases (as it does with age).

Our first IUIs were with femara and no trigger. I think we tried 3 or 4 cycles? Can't remember now because it's been a few years. I just wasn't quite ready mentally to jump to IVF even though the RE pointed out that our chances would be higher. On our first IVF cycle I had 5 eggs which were fertilized with ICSI. My DH has "super sperm," but with my few, fragile eggs they wanted to increase the odds. Only one fertilized and it stopped dividing at 4 cells. My poor response and my obvious egg issue was devastating. We decided to try one more IVF cycle with my eggs. On the second cycle we got 7 eggs. I was thrilled with that! Unfortunately, only 2 fertilized with ICSI and those stopped dividing at 3 and 4 cells. No transfer. Again. I knew I wanted to experience a pregnancy and felt like I had exhausted the possibility of using my own eggs. I was OK with using donor eggs at that point, but we didn't have the financial option of going that route yet. I decided that we should at least use up the Follistim that was leftover (almost $1000 of meds sitting in the veggie drawer of the fridge). I decided I would try acupuncture for 3 cycles prior to an injectable/IUI cycle. My acupuncturist was the only one who seemed optimistic at that point although our RE always said things like, "anything is possible." I produced three follicles by trigger time and was blessed with the healthy pregnancy that resulted in my DS. I still get teary-eyed thinking of how blessed I am. I don't know why it happened when it did, but when I read other stories it seems like it just takes longer for women with low ovarian reserve. There's another good board out there specifically for women with high fsh (or low amh), but I can't think of the name right now. If you're interested, I can find it again. I'm mrs.doolittle on there, too. Wink

Will you let me know where to find the board on low ovarian reserve? I'd love to get some ideas on suggestions for my future IUI's.

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Kadi PGD is where they test the embros before they put them back into you. If you use your sister eggs do you have to use a lawyer and how much would something like that cost. Im interested in someone carrying my babies.

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"kadibug" wrote:

Will you let me know where to find the board on low ovarian reserve? I'd love to get some ideas on suggestions for my future IUI's.

http://www.fertilethoughts.com/forums/high-fsh-premature-ovarian-failure/

I haven't been on there in a while, but found it very helpful to find a large group of women with the same diagnosis. It was very encouraging for me to read success stories. I think I'll re-visit them now that I'm thinking about it!

Looks like dreamchaser might be there, too. Wink

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I am! Smile I was just checking to see if you'd responded to this thread Beth. I was going to say that I thought fertilethoughts was the forum you were referring to. Smile

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oh... pgd, well that was discussed with the RE. he said it's something to consider if we use my eggs. if we use my sister's, we'll only need a lawyer for the birth certificate (i think) as my sister has no desire to have more children. the cost to use a donor egg is about 17k at my clinic here. unfortunately, we'd probably have to go to washington state and use the clinic closest to my sister... and i don't know their costs. i hope it's not more than 17k - that's CRAZY.

fyi - my sister said that she wouldn't be a surrogate, so it would really be egg donation only.

"reneakelly" wrote:

Kadi PGD is where they test the embros before they put them back into you. If you use your sister eggs do you have to use a lawyer and how much would something like that cost. Im interested in someone carrying my babies.